The Zijinshan high-sulfidation epithermal Cu-Au deposit is located in the Zijinshan ore field of South China, comprising porphyry-epithermal Cu-Au-Mo-Ag ore systems. The Cu ore body is more than 1000 m thick and is characterized by an assemblage of digenite-covellite-enargite-alunite. Digenite is the dominant Cu-bearing mineral, which makes this deposit unique, although the mechanisms of digenite formation remain controversial. To elucidate the genesis of digenite, this paper presents the Cu isotopic compositions of Cu-sulfides in the Zijinshan high-sulfidation Cu-Au deposit. The Cu isotopic values (Cu-65 relative to NIST 976) of all samples range from -2.97 parts per thousand to +0.34 parts per thousand, and most values fall in a narrow range from -0.49 parts per thousand to +0.34 parts per thousand, which is similar to the Cu isotopic signature of typical porphyry systems. Copper isotope ratios of each mineral decrease with increasing depth, a trend that is also typical of porphyry deposits. The variation tendency of delta Cu-65 values between sulfides is consistent with the sequence of mineral formation. These observations suggest that the Cu-sulfides in the Zijinshan Cu-Au deposit have a hypogene origin. (C) 2016 Elsevier B.V. All rights reserved.